Serum concentrations of tumour necrosis factor alpha in childhood chronic inflammatory bowel disease.

摘要: Serum tumour necrosis factor alpha (TNF alpha) concentrations were measured by enzyme linked immunoadsorbent assay in 31 normal children and during 65 episodes of clinical remission 54 relapse 92 with chronic inflammatory bowel disease. An appreciable rise TNF was found only ulcerative colitis colonic Crohn's The group small disease did not show increases above control concentrations, despite an equivalent indices. Height velocity depressed large compared the condition remission. impairment growth significantly greater than alone, although for subgroups stage 1 puberty (prepubertal) differences significant. Inadequate is currently ascribed to inadequate nutrition may contribute this through its cachexia inducing effects. It may, addition, diminish pituitary hormone release. These results suggest that production be associated failure