Impact of trough IgG on pneumonia incidence in primary immunodeficiency: A meta-analysis of clinical studies.

摘要: Primary immunodeficiency disease (PIDD) associated with hypogammaglobulinemia is typically treated immunoglobulin replacement therapy. When administered as intravenous (IVIG), an IgG trough occurs prior to the next dose. While frequently measured, levels required minimize infection risk are not established. To address this question, all available studies evaluating and pneumonia incidence in PIDD patients receiving IVIG were quantitatively combined by meta-analysis. Seventeen 676 total 2,127 patient-years of follow-up included. Pneumonia declined 27% each 100mg/dL increment (incidence rate ratio, 0.726; 95% confidence interval, 0.658-0.801). maintenance 500 mg/dL (0.113 cases per patient-year) was 5-fold that 1000 (0.023 patient-year). This meta-analysis provides evidence can be progressively reduced higher up at least mg/dL.