Association of dopamine receptor D2 gene (DRD2) Taq1 polymorphisms with eating behaviors and obesity among Chinese and Indian Malaysian university students.

摘要: Background and Objectives: This study investigated the association of DRD2 Taq1A, Taq1B Taq1D gene polymorphisms with eating behavior, preference/intake frequency/craving high-fat foods obesity in 394 Malaysian adults (161 males, 233 females; 308 Chinese, 86 Indians; 67 obese, 327 non-obese). Methods Study Design: Eating behaviors namely Cognitive Restraint, Uncontrolled Emotional scores were assessed by Three Factor Questionnaire-R18. The 26 common was using a 7-point hedonic scale. Anthropometric measurements taken Taq1 genotyped PCR-Restriction Fragment Length Polymorphism DNA extracted from mouthwash samples. Results: overall minor allele frequencies according to ethnicities (Chinese/Indian) 0.37/0.29, 0.39/0.28, 0.06/0.30, respectively; genotype distributions significantly different between ethnicities. behavior not gender Those A1 or B1 had lower Restraint score higher score, while those A1/A1 B1/B1 fast food preference. D1 associated increased starchy craving mamak (Malaysian Indian-Muslim) preference, but scores. All three variants adiposity. Conclusion: Taken together, we posit that influence certain adults, their role adiposity is still inconclusive needs further investigation.