Antimicrobial activity of volatile and non-volatile isolated compounds and extracts from the bark and leaves of Warburgia salutaris (Canellaceae) against skin and respiratory pathogens
作者： G.P. Khumalo , N.J. Sadgrove , S. Van Vuuren , B.-E. Van Wyk
DOI: 10.1016/J.SAJB.2018.10.018
关键词:
摘要: Abstract Warburgia salutaris is one of the most popular trees used in traditional medicine throughout tropical southeast Africa, because its ability to treat a wide variety illnesses caused by fungi, bacteria, viruses and insects. The aim study was test antimicrobial activity W. isolated compounds against selected skin respiratory pathogens. Furthermore, investigate main chemical this species compare their activities with previously published studies. Crude extracts, essential oils from bark salutaris, showed pathogens (Pseudomonas aeruginosa ATCC 743971 Staphylococcus aureus 25923) tract (Klebsiella pneumoniae 13883 Moraxella catarrhalis 23246). Bioassay guided fractionation dichloromethane extract (muthi market sample) oil (from cultivated tree) yielded six compounds, which included two major components drimenol (1) E-nerolidol (2) less volatile drimane sesquiterpenes muthi bark: 12α-acetal-polygodial (3), polygodial (4), ugandensidial (5) warburganal (6). Noteworthy M. observed 2 minimum inhibitory concentration 31 μg/ml 4 an MIC 25 μg/ml K. pneumoniae. This first report 1,2 3 identification these could explain use as inhalation therapy ailments. Despite numerous studies, composition biological leaves are not yet fully explored.
sci-hub.se 参考文章(27)
C. Pottas-Bircher, E. E. Snyman, C. A. Prentice, T. H. Arnold, N. R. Crouch, L. C. Hawker, M. Tomalin, Medicinal and magical plants of southern Africa: an annotated checklist. Medicinal and magical plants of southern Africa: an annotated checklist.. ,(2002)
N. Gericke, B. E. van Wyk, People's Plants: A Guide to Useful Plants of Southern Africa ,(2000)
Anne Hutchings, Zulu Medicinal Plants: An Inventory ,(1996)
Viresh Mohanlall, Bharti Odhav, Furans and furanones with antimycotoxigenic activity isolated from Warburgia salutaris (Canellaceae). Journal of Medicinal Plants Research. ,vol. 3, pp. 231- 240 ,(2009)
Isao Kubo, Makoto Taniguchi, Polygodial, an antifungal potentiator. Journal of Natural Products. ,vol. 51, pp. 22- 29 ,(1988) , 10.1021/NP50055A002
Heidrun Anke, Olov Sterner, Comparison of the antimicrobial and cytotoxic activities of twenty unsaturated sesquiterpene dialdehydes from plants and mushrooms. Planta Medica. ,vol. 57, pp. 344- 346 ,(1991) , 10.1055/S-2006-960114
Samísia Maria Fcrnandes Machado, Valdir Alves Facundo Adauto Ribeiro, Julio Sancho L. T. Militão, Selene Maia de Morais, Maria Iracema Lacerda Machado, Seasonal Variation of (E)-Nerolidol in Siparuna guianensis Aublet and 13C-NMR Spectral Assignments of (E)- and (Z)-Nerolidol Journal of Essential Oil Research. ,vol. 10, pp. 708- 710 ,(1998) , 10.1080/10412905.1998.9701017
Yoshiyasu Fukuyama, Tsuneo Sato, Yoshinori Asakawa, Tsunematsu Takemoto, A potent cytotoxic warburganal and related drimane-type sesquiterpenoids from Polygonum hydropiper Phytochemistry. ,vol. 21, pp. 2895- 2898 ,(1980) , 10.1016/0031-9422(80)85063-1
M Mashimbye, A drimane sesquiterpenoid lactone from Warburgia salutaris Phytochemistry. ,vol. 51, pp. 435- 438 ,(1999) , 10.1016/S0031-9422(98)00753-5
N. Gericke, B. van Oudtshoorn, B. E. van Wyk, Medicinal plants of South Africa ,(1997)