DRUGS AND TOXIC AGENTS

摘要: Fluorometric assay is a potent tool for the sensitive assays that are required to establish relationships between biochemical and pharmacological activity. It also necessary accumulating chemical data correlate with clinical observations during early intermediate stages of drug development. This chapter describes fluorescence studies on wide variety agents toxic or pharmacologically active. A large number drugs basic in nature, it possible make use this property analytical purposes. has been shown water-soluble acidic dyes, such as methyl orange, eosin, bromphenol blue, can form complexes organic bases extractable into solvents. As dye not extracted, color solvent measure base. Such colorimetric procedures have applied including cinchona alkaloids demerol. The same methodology could be developed fluorescent dyes increase sensitivity analyses.