作者: Monica Suresh Allen , Kambiz Alavi
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摘要: The specific aims of this dissertation were to develop: (1) Correlations between experimental protocols and oxygenated, deoxygenated, total hemoglobin concentrations in the brain; (2) Mathematical models associate blood flow oxygen consumption rate activated brain regions with measured hemodynamic changes; (3) A phantom that vasculature compliance validate developed mathematical a controlled setup. primary imaging modality used experimentation phase research was near infrared spectroscopy. Previously published multimodality measurements also models. The single compartment Windkessel model extended describe flow-volume dynamics during long duration stimulus include transport tissue. An inductive multi-compartment which enables estimation compartmentalized changes modeling oxy- deoxyhemoglobin based on pseudo-Bayesian framework for data. In addition, solution deductive neurovascular developed. This defines relationship presented neural activity it elicits turn gives rise vascular changes. Finally laboratory - volume relationships using compliant vasculature.