Models and algorithms to determine cerebral activation using near infrared spectroscopy

作者: Monica Suresh Allen , Kambiz Alavi

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摘要: The specific aims of this dissertation were to develop: (1) Correlations between experimental protocols and oxygenated, deoxygenated, total hemoglobin concentrations in the brain; (2) Mathematical models associate blood flow oxygen consumption rate activated brain regions with measured hemodynamic changes; (3) A phantom that vasculature compliance validate developed mathematical a controlled setup. primary imaging modality used experimentation phase research was near infrared spectroscopy. Previously published multimodality measurements also models. The single compartment Windkessel model extended describe flow-volume dynamics during long duration stimulus include transport tissue. An inductive multi-compartment which enables estimation compartmentalized changes modeling oxy- deoxyhemoglobin based on pseudo-Bayesian framework for data. In addition, solution deductive neurovascular developed. This defines relationship presented neural activity it elicits turn gives rise vascular changes. Finally laboratory - volume relationships using compliant vasculature.

参考文章(131)
Maria Angela Franceschini, Vlad Toronov, Enrico Gratton, Sergio Fantini, Mattia E. Filiaci, Cerebral Hemodynamics Measured by Near-Infrared Spectroscopy at Rest and During Motor Activation ,(2000)
Jeremy C. Hebden, Elizabeth M. C. Hillman, Adam Gibson, Nick Everdell, Rozarina Md. Yusof, David T. Delpy, Simon R. Arridge, Topun Austin, Judith H. Meek, Time resolved optical imaging of the newborn infant brain: initial clinical results Biomedical Topical Meeting (2002), paper TuE2. ,(2002) , 10.1364/BIO.2002.TUE2
Karl J. Friston, William Penny, Olivier David, Modeling brain responses. International Review of Neurobiology. ,vol. 66, pp. 89- 124 ,(2005) , 10.1016/S0074-7742(05)66003-5
Abraham Noordergraaf, Circulatory system dynamics ,(1978)
Gerald Grabner, Rupert Kittinger, Andrés Kecskeméthy, An Integrated Runge-Kutta and Polynomial Root Finding Method for Reliable Event-Driven Multibody Simulation IFAC Proceedings Volumes. ,vol. 36, pp. 251- 256 ,(2003) , 10.1016/S1474-6670(17)38900-0
Hanli Liu, Yueqing Gu, Jae G Kim, Ralph P Mason, None, Near-infrared spectroscopy and imaging of tumor vascular oxygenation. Methods in Enzymology. ,vol. 386, pp. 349- 378 ,(2004) , 10.1016/S0076-6879(04)86017-8
Charles W. Kerber, Kimberly Knox, Steven G. Imbesi, Aneurysm flow dynamics: alterations of slipstream flow for neuroendovascular treatment with liquid embolic agents. American Journal of Neuroradiology. ,vol. 24, pp. 2044- 2049 ,(2003)
John Mayhew, Dewen Hu, Ying Zheng, Steven Askew, Yuqian Hou, Jason Berwick, Peter J. Coffey, Nicky Brown, An Evaluation of Linear Model Analysis Techniques for Processing Images of Microcirculation Activity NeuroImage. ,vol. 7, pp. 49- 71 ,(1998) , 10.1006/NIMG.1997.0311
Brian Knutson, Andrew Westdorp, Erica Kaiser, Daniel Hommer, FMRI Visualization of Brain Activity during a Monetary Incentive Delay Task NeuroImage. ,vol. 12, pp. 20- 27 ,(2000) , 10.1006/NIMG.2000.0593
Hartwig Siebner, Matthias Riemenschneider, Frode Willoch, Satoshi Minoshima, Markus Schwaiger, Alexander Kurz, Alexander Drzezga, Nicola Lautenschlager, Cerebral metabolic changes accompanying conversion of mild cognitive impairment into Alzheimer's disease: a PET follow-up study. European Journal of Nuclear Medicine and Molecular Imaging. ,vol. 30, pp. 1104- 1113 ,(2003) , 10.1007/S00259-003-1194-1