Chemerin: A Comprehensive Review Elucidating the Need for Cardiovascular Research

摘要: When chemerin was discovered in 1997, it relegated to being a protein associated with the normal skin function contrasting setting of psoriasis. However, discovery multiple receptors for and vast collection associations various pathologies, has global influence capable regulating chemotactic, adipokine, autocrine/paracrine, adipogenic, angiogenic, reproductive functions. These individual abilities are important understanding its basic pharmacology physiology, but application these principles human pathology relies on ability scientists physicians view this from much wider, all-encompassing angle. A participant action is cardiovascular system (CVS). Although CVS may not have as many direct interactions (e.g. smooth muscle endothelium) does indirect activation lumen by proteases), our relation necessary form proper grasp actions make applications pathology. This review provides fundamental, yet comprehensive that inherently identifies link between also calls research solution chasm knowledge application.