A population-based study of infection-related hospital mortality in patients with dermatomyositis/polymyositis.

摘要: Objective Dermatomyositis (DM) and polymyositis (PM) are debilitating inflammatory myopathies associated with significant mortality. We evaluated the relative contribution of infection to hospital mortality in a large population-based study individuals PM/DM. Methods Data derive from 2007 2011 Healthcare Cost Utilization Project National Inpatient Samples include all discharges that met validated administrative definition PM/DM. The primary outcome was Variables for infections comorbidities were generated discharge diagnoses using definitions. Logistic regression used investigate relationship between PM/DM, adjusting sociodemographics, utilization variables, comorbidities. Relative risks (RRs) calculated compare overall prevalence specific PM/DM hospitalizations those seen general hospitalized population. Results A total 15,407 inclusion criteria this inpatient 4.5% (700 deaths). In adjusted logistic analyses, (odds ratio [OR] 3.4, 95% confidence interval [95% CI] 2.9–4.0) strongest predictor among Bacterial (OR 3.5, CI 3.0–4.1), comprised primarily pneumonia bacteremia, opportunistic fungal 2.5, 1.5–4.0) independently burden significantly increased comparison population (RR 1.5, 1.4–1.6). Conclusion Among is leading cause Strategies mitigate risk both clinic settings should be improve disease outcomes.