Secretory function of ovarian cells and myometrial contractions in cow are affected by chlorinated insecticides (chlordane, heptachlor, mirex) in vitro

摘要: Abstract The aim of the study was to investigate effect chlordane, heptachlor and mirex, on hormonal regulation force myometrial contractions. Myometrial, endometrial, granulosa luteal cells as well strips myometrium from non-pregnant cows were incubated with three insecticides at environmentally relevant doses (0.1, 1 or 10 ng/ml). None affected viability studied cells. Chlordane stimulated, while mirex inhibited, secretion testosterone estradiol progesterone cells, respectively. Secretion oxytocin (OT) increased after incubation all insecticides. Only stimulated OT inhibited this effect. them synthesis in prostaglandins (PGF2 PGE2) uterine except PGE2 endometrial decreased when 0.1 ng/ml chlordane. Basal OT-stimulated contractions by heptachlor. data show that altered secretory function ovarian Heptachlor also vitro , but not involved mechanism adverse indicate potential these disturb fertilisation, blastocyst implantation even length gestation.