Sex differences in brain MRI abnormalities and neurodevelopmental outcomes in a rat model of neonatal hypoxia-ischemia
作者： Hui-Zhi Huang , Xiao-Hong Wen , Hui Liu
DOI: 10.3109/00207454.2015.1047016
关键词:
摘要: Purpose/aim of the study: Hypoxic-ischemic brain injury (HIBI) is associated with high mortality and neurodevelopmental deficits. We explored gender influence in a HIBI rat model. Materials methods: Sprague–Dawley rats underwent on postnatal day (P) 7. Nervous reflexes, footprints, Morris water maze performances magnetic resonance imaging (MRI) were analyzed. Results: Mortality rate was higher males (20%) than females (12.5%). Growth slower group (p < 0.05), but similar between females. showed impaired cliff aversion reflex, negative geotaxis reflex gait tests at P14 not P9 or P11. There no significant differences for genders. Negative impairment more severe 0.05). Step length toe distance contralateral (but ipsilateral) to cerebral damage shorter rats, short...
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