PSA density improves prediction of prostate cancer.

摘要: INTRODUCTION Prostate-specific antigen (PSA) and the digital rectal exam (DRE) have moderate sensitivity but low specificity for cancer diagnosis, potentially causing unnecessary treatment complications with prostate biopsy. Transrectal ultrasound (TRUS) to evaluate size calculate PSA density can improve of in predicting cancer. We evaluated different pre-biopsy tests detect MATERIALS AND METHODS Pre-biopsy data were collected from 521 men referred biopsy January-December 2011 aggressiveness 96 who had radical prostatectomy. Model predictors included total PSA, DRE, ratio free (PSAf/t), density. used logistic regression ROC curve analyses compare accuracy models predict positive RESULTS The area under (AUC) model A (PSA total, PSAf/t) was moderate, significant (AUC = .59, p < .05); only PSAf/t a independent predictor (OR .002, .05). In B (PSAf/t density; AUC= .66, .05), strong 1067.93, Both comparable (74% versus 72%) greater (44% 61%). also indices aggressive CONCLUSIONS has discriminative predictive power It similar sensitivity, compared using DRE PSAf/t. These results support value prediction reduce biopsies.