Structure and functional expression of a human interleukin-8 receptor.
作者： W. Holmes , J Lee , W. Kuang , G. Rice , W. Wood
关键词:
摘要: Interleukin-8 (IL-8) is a member of family pro-inflammatory cytokines. Although the best characterized activities IL-8 include chemoattraction and activation neutrophils, other members this have wide range specific actions including chemotaxis monocytes, selective memory T cells, inhibition hematopoietic stem cell proliferation, induction neutrophil infiltration in vivo. A complementary DNA encoding receptor from human neutrophils has now been isolated. The amino acid sequence shows that superfamily receptors couple to guanine nucleotide binding proteins (G proteins). 29% identical for chemoattractants, fMet-Leu-Phe C5a. Mammalian cells transfected with cDNA clone bind high affinity respond specifically by transiently mobilizing calcium. may be part subfamily related G protein-coupled transduce signals
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