Human stem cell model of HNF1A deficiency shows uncoupled insulin to C-peptide secretion with accumulation of abnormal insulin granules
作者： Rudolph L Leibel , Jesper Gromada , Jose Oberholzer , Charles A LeDuc , Yufeng Shen
DOI: 10.1101/2021.01.26.428260
关键词:
摘要: … of secreted insulin to C-peptide. In HNF1A deficient β-cells, … by glucose, and restores C-peptide and insulin secretion to a … proportions of insulin:C-peptide in nine MODY3 patients. …
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