Synthetic human peptides and pharmaceutical compositions comprising them for the treatment of systemic lupus erythematosus

作者: Edna Mozes

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摘要: Synthetic peptides of at least 12 and most 30 amino acid residues comprising a sequence consisting of, or found within, complementarity-determining region (CDR) in the heavy light chain human anti-DNA 16/6Id monoclonal antibody, obtained by replacement and/or deletion addition one more to said sequence, salts, chemical derivatives polymers can be used for immunomodulation systemic lupus erythematosus-associated responses.

参考文章(65)
Pierre Monsan, Francois Paul, Didier Betbeder, Paolo Sarmientos, Process for the enzymatic preparation of basic fibroblast growth factor ,(1991)
P J Conlon, A rapid biologic assay for the detection of interleukin 1. Journal of Immunology. ,vol. 131, pp. 1280- 1282 ,(1983)
Joseph Rubinfeld, Warren Stern, Gregory J. Wong, Maninder Singh Hora, Method and compositions for solubilization and stabilization of polypeptides, especially proteins ,(1989)
P Sarén, H G Welgus, P T Kovanen, TNF-alpha and IL-1beta selectively induce expression of 92-kDa gelatinase by human macrophages. Journal of Immunology. ,vol. 157, pp. 4159- 4165 ,(1996)
Thomas Charles Furman, James Patrick Mcdonough, Gerald Wayne Becker, Warren C. Mackellar, Enzymatic removal of a protein amino-terminal sequence ,(1990)
Adnan Badwan, Hussein Ibrahim, Muwaffak Haddadin, Abdullah Abumalooh, Method for solubilizing drugs using cyclodextrins and carboxylic acids ,(1995)
Harald Fricke, Daniel Offen, Shlomo Mendlovic, Yehuda Shoenfeld, Ronit Bakimer, Joseph Sperling, Edna Mozes, Induction of experimental systemic lupus erythematosus in mice by immunization with a monoclonal anti-La autoantibody International Immunology. ,vol. 2, pp. 225- 230 ,(1990) , 10.1093/INTIMM/2.3.225
A. N Theofilopoulos, B. R Lawson, Tumour necrosis factor and other cytokines in murine lupus Annals of the Rheumatic Diseases. ,vol. 58, pp. 149- ,(1999) , 10.1136/ARD.58.2008.I49
S. Mendlovic, S. Brocke, Y. Shoenfeld, M. Ben-Bassat, A. Meshorer, R. Bakimer, E. Mozes, Induction of a systemic lupus erythematosus-like disease in mice by a common human anti-DNA idiotype Proceedings of the National Academy of Sciences of the United States of America. ,vol. 85, pp. 2260- 2264 ,(1988) , 10.1073/PNAS.85.7.2260