Susceptibility test methods: parasites.

作者: Jacques Le Bras , Jérôme Clain , W. Evan Secor

DOI: 10.1128/9781555817381.CH151

关键词:

摘要: Drug susceptibility tests fall into four broad categories: in vivo tests, vitro with experimental animals, and molecular tests. These different categories of provide complementary information. At one end the spectrum, analyze parasites at their most basic biologic level, without any outside interference. Most drug resistance malaria concern Plasmodium falciparum, prevalent virulent species prone to development resistance. Incorporating pharmacokinetic parameters is now considered essential for true identification within partners artemisinins, which are frequently poorly absorbed or slowly eliminated drugs. While treatment failures Trichomonas vaginalis infections have often been disregarded as being due poor patient compliance rapid reinfection, there an increasing recognition that clinical exists may be increasing, thus necessitating accurate testing isolates. Treatment failure leishmaniasis result from either immunodeficiencies preclude effective chemotherapeutic action. Differentiation these two possibilities important both individual care general public health. A standardized method detection was designed trypanosomes infect cattle can also applied those humans. Investigation mechanisms schistosomes more difficult time-consuming than associated protozoan infections.

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