Effect of sepsis on mucosal protein synthesis in different parts of the gastrointestinal tract in rats.
作者： Takashi Higashiguchi , Yoshifumi Noguchi , William O'Brien , Kenneth Wagner , Josef E. Fischer
DOI: 10.1042/CS0870207
关键词:
摘要: 1. In a previous study we found that the protein synthesis rate was increased by 50-60% in mucosa of jejunum and ileum during sepsis rats. It is not known if affects turnover other parts gastrointestinal tract as well. 2. present study, influence on mucosal different tract, from stomach to rectum, determined 3. Sepsis induced caecal ligation puncture; control rats underwent sham-operation. Protein measured vivo after administration flooding dose [14C]leucine. 4. Basal rates were lower colon than rest tract. Sixteen hours puncture, 40-85% small large intestine whereas gastric mucosa, reduced approximately 40%. 5. The results suggest differ various regions metabolic response finding may partly explain tendency stress ulcers bleeding seen clinically sepsis.
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Arthur E. Baue, Keith A. Wichterman, Irshad H. Chaudry, Effect of sepsis on tissue adenine nucleotide levels. Surgery. ,vol. 85, pp. 205- 211 ,(1979) , 10.5555/URI:PII:0039606079903064
P. J. Garlick, M. A. McNurlan, P. Essen, J. Wernerman, Measurement of tissue protein synthesis rates in vivo: a critical analysis of contrasting methods American Journal of Physiology-endocrinology and Metabolism. ,vol. 266, ,(1994) , 10.1152/AJPENDO.1994.266.3.E287
A. Lewis Farr, Oliver H. Lowry, Rose J. Randall, Nira J. Rosebrough, Protein Measurement with the Folin Phenol Reagent Journal of Biological Chemistry. ,vol. 193, pp. 265- 275 ,(1951)
M A McNurlan, A M Tomkins, P J Garlick, The effect of starvation on the rate of protein synthesis in rat liver and small intestine Biochemical Journal. ,vol. 178, pp. 373- 379 ,(1979) , 10.1042/BJ1780373
Oded Zamir, Per-Olof Hasselgren, Takashi Higashiguchi, Janice A. Frederick, Josef E. Fischer, Effect of sepsis or cytokine administration on release of gut peptides American Journal of Surgery. ,vol. 163, pp. 181- 185 ,(1991) , 10.1016/0002-9610(92)90273-T
L. R. Da Costa, D. N. Croft, B. Creamer, Protein loss and cell loss from the small-intestinal mucosa Gut. ,vol. 12, pp. 179- 183 ,(1971) , 10.1136/GUT.12.3.179
Marianne Hall-Angerås, Ulf Angerås, Daniel von Allmen, Takashi Higashiguchi, Oded Zamir, Per-Olof Hasselgren, Josef E. Fischer, Influence of sepsis in rats on muscle protein turnover in vivo and in tissue incubated under different in vitro conditions Metabolism. ,vol. 40, pp. 247- 251 ,(1991) , 10.1016/0026-0495(91)90105-6
Robert P. Hummel, Per-Olof Hasselgren, J.Howard James, Brad W. Warner, Josef E. Fischer, The effect of sepsis in rats on skeletal muscle protein synthesis in vivo and in periphery and central core of incubated muscle preparations in vitro. Metabolism-clinical and Experimental. ,vol. 37, pp. 1120- 1127 ,(1988) , 10.1016/0026-0495(88)90187-4
M.W. Smith, R.M. Moor, Protein synthesis and secretion by hamster, rat and mouse jejunum. Comparative Biochemistry and Physiology B. ,vol. 78, pp. 379- 387 ,(1984) , 10.1016/0305-0491(84)90046-4
Donald A. Plumley, Accelerated Lung Amino Acid Release in Hyperdynamic Septic Surgical Patients Archives of Surgery. ,vol. 125, pp. 57- 61 ,(1990) , 10.1001/ARCHSURG.1990.01410130063008