Dietary modulation of endothelial function: implications for cardiovascular disease

摘要: The vascular endothelium is the primary site of dysfunction in many diseases, particularly cardiovascular disease. A variety risk factors, including smoking, hypercholesterolemia, hyperhomocysteinemia, hypertension, and diabetes mellitus, adversely affect endothelial function. Emerging evidence suggests an important role dietary factors modulating In particular, n-3 fatty acids, antioxidant vitamins (especially E C), folic acid, L-arginine appear to have beneficial effects on function, either by decreasing activation or improving endothelium-dependent vasodilation patients at high disease as well healthy subjects. These may serve one potential mechanism through which these nutrients reduce disease, observed epidemiologic studies several clinical trials. This article reviews experimental regarding function their prevent