EBAG9/RCAS1 in human breast carcinoma: a possible factor in endocrine-immune interactions.
作者： T Suzuki , S Inoue , W Kawabata , J Akahira , T Moriya
关键词:
摘要: EBAG9 has been recently identified as an oestrogen responsive gene in MCF-7 human breast carcinoma cells. is identical to RCAS1, a cancer cell surface antigen possibly involved immune escape. In this study, we examined the expression of EBAG9/RCAS1 carcinomas using immunohistochemistry and reverse transcription-polymerase chain reaction (RT-PCR). immunoreactivity was also associated with various clinicopathological parameters, including intratumoural infiltration inflammatory cells, examine biological significance carcinomas. detected entire cytoplasm cells 82 out 91 invasive ductal (90.1%). non-neoplastic mammary glands, weakly present on luminal epithelial Results from RT-PCR (n = 7) were consistent those immunohistochemistry. significantly estrogen receptor (ER) α labelling index (P 0.0081), inversely degree mononuclear 0.0020), or CD3+ T lymphocytes 0.0025). This study suggests that produced via ER inhibits context possible endocrine–immune interaction © 2001 Cancer Research Campaign http://www.bjcancer.com
nature.com
sci-hub.se 参考文章(43)
T Pietruk, J D Crissman, G Cummings, T An, U Sood, K Hashimoto, In situ quantitation of inflammatory mononuclear cells in ductal infiltrating breast carcinoma. Relation to prognostic parameters. American Journal of Pathology. ,vol. 128, pp. 52- 60 ,(1987)
H J G Bloom, W W Richardson, Histological grading and prognosis in breast cancer; a study of 1409 cases of which 359 have been followed for 15 years. British Journal of Cancer. ,vol. 11, pp. 359- 377 ,(1957) , 10.1038/BJC.1957.43
Manabu Nakashima, Kenzo Sonoda, Takeshi Watanabe, Inhibition of cell growth and induction of apoptotic cell death by the human tumor-associated antigen RCAS1. Nature Medicine. ,vol. 5, pp. 938- 942 ,(1999) , 10.1038/11383
K.B. Horwitz, W.L. McGuire, Estrogen control of progesterone receptor in human breast cancer. Correlation with nuclear processing of estrogen receptor. Journal of Biological Chemistry. ,vol. 253, pp. 2223- 2228 ,(1978) , 10.1016/S0021-9258(17)38062-6
Helmut Dotzlaw, Leigh C. Murphy, Peter H. Watson, Etienne Leygue, Estrogen receptor-beta messenger RNA expression in human breast tumor biopsies: relationship to steroid receptor status and regulation by progestins. Cancer Research. ,vol. 59, pp. 529- 532 ,(1999)
Hiroshi Nagura, Haruo Ohtani, Akio Ohuchi, Kenichi Shiiba, Yoshitaka Naito, Kazuya Saito, Katsunori Saigenji, CD8+ T Cells Infiltrated within Cancer Cell Nests as a Prognostic Factor in Human Colorectal Cancer Cancer Research. ,vol. 58, pp. 3491- 3494 ,(1998)
Yoshinori Hamada, Manabu Yamamura, Kohshiro Hioki, Masakatsu Yamamoto, Hiroshi Nagura, Keiichi Watanabe, Immunohistochemical study of carcinoembryonic antigen in patients with colorectal cancer. Correlation with plasma carcinoembryonic antigen levels Cancer. ,vol. 55, pp. 136- 141 ,(1985) , 10.1002/1097-0142(19850101)55:1<136::AID-CNCR2820550121>3.0.CO;2-P
Eva Enmark, Markku Pelto-Huikko, Kaj Grandien, Svetlana Lagercrantz, Jacob Lagercrantz, Gabriel Fried, Magnus Nordenskjöld, Jan-Åke Gustafsson, Human estrogen receptor β-gene structure, chromosomal localization, and expression pattern The Journal of Clinical Endocrinology and Metabolism. ,vol. 82, pp. 4258- 4265 ,(1997) , 10.1210/JCEM.82.12.4470
Reijo Vihko, Dan Apter, R.D. Bulbrook, Endogenous steroids in the pathophysiology of breast cancer Critical Reviews in Oncology/Hematology. ,vol. 9, pp. 1- 16 ,(1989) , 10.1016/S1040-8428(89)80012-5
Charles M Balch, Lee B Riley, Yoon Joo Bae, Marie A Salmeron, Chris D Platsoucas, Andrew Von Eschenbach, Kyogo Itoh, Patterns of Human Tumor-Infiltrating Lymphocytes in 120 Human Cancers Archives of Surgery. ,vol. 125, pp. 200- 205 ,(1990) , 10.1001/ARCHSURG.1990.01410140078012