Growth inhibition by acycloguanosine of herpesviruses isolated from human infections.

摘要: Inhibition by acycloguanosine (ACG) of plaque formation harpes simplex virus types 1 and 2 (HSV-1 HSV-2), varicella-zoster virus, cytomegalovirus was studied. Seventeen clinical isolates HSV-1 were inhibited ACG at a mean 50% inhibitory dose (ID 50 ) 0.15 ± 0.09 μM. The ID for 10 HSV-2 1.62 0.76 μM, four it 3.75 1.30 9s two 100 160 additional no end point reached 200 concentration μM had effect on deoxyribonucleic acid synthesis in human fibroblast cells only thymidine incorporation Vero one-third. These studies demonstrated the antiviral activity against HSV-1, HSV-2, lack toxicity to monkey or culture concentrations which markedly these viruses. little excess