[Long-term decrease of microalbuminuria after one year of treatment with perindopril in hypertensive diabetic patients].

摘要: We studied the effects of perindopril, an angiotensin converting enzyme (ACE) inhibitor administered during 12 months, on creatinine clearance, albuminuria and glycaemic control in diabetic subjects with mild to moderate hypertension. After 1 month placebo, 40 insulin-treated patients were divided into 3 groups based upon their urinary albumin excretion rate. Group had a normoalbuminuria (less than 15 mg/24 h), group II microalbuminuria (15-150 h) III macroproteinuria (greater 150 h Albustix +). They given perindopril 4 8 mg orally once daily, received stable diet. Diastolic blood pressure was normalized within first months 80% patients. From these, 28 (14.7 7 from I, respectively) followed total active treatment period months. matched for age, duration diabetes hypertension, systolic diastolic pressures, daily insulin dose, postprandial plasma C-peptide quality control. Mean supine decreased by 18% at respectively. Heart rate not significantly modified. At ACE activity nearly totally inhibited while renin markedly increased. In II, reduced 66 +/- 13 (mean SEM after placebo) 39 6 this effect maintained remained normal range. III, consistently modified perindopril. Creatinine clearance did change throughout study groups. No major side observed. conclude that normalizes large majority hypertensive without affecting It also induces marked sustained reduction risk developing nephropathy.