Clozapine and risperidone in chronic schizophrenia: Effects on symptoms, Parkinsonian side effects, and neuroendocrine response

摘要: OBJECTIVE: Clozapine and risperidone were the first two “second-generation” antipsychotic drugs approved for schizophrenia. There is currently little information about their comparative efficacy from head-to-head clinical trials. The purpose of this study was to examine clozapine positive negative symptoms, depression, parkinsonian side effects, indexes neuroendocrine function in schizophrenic patients who met a priori criteria partial response traditional neuroleptic agents. METHOD: After baseline fluphenazine treatment period, 29 participated 6-week, double-blind, parallel-group comparison effects these RESULTS: superior symptoms but there no significant differences between on measures Brief Psychiatric Rating Scale total scores, depression scores. patients, not rispe...