Eosinophilia-myalgia syndrome, toxic-oil syndrome, and diffuse fasciitis with eosinophilia.

摘要: The similarity of eosinophilia-myalgia syndrome (EMS) and toxic-oil (TOS) to systemic sclerosis diffuse fasciitis with eosinophilia (DFE) highlights the potential for environmental agents induce autoimmune disease. Further, a candidate etiologic agent EMS, 3-(phenylamino)alanine, is chemically similar aniline derivative identified in samples oil implicated TOS, 3-(N-phenylamino)-1,2-propanediol, suggesting pathogenic overlap. late-stage manifestations EMS TOS are muscle cramping, arthralgia, severe fatigue, cognitive impairment. This review focuses on divergent parallel findings DFE. formation Environmentally Associated Connective Tissue Disease Study Croup within American College Rheumatology will provide forum development registries study suspected toxin-induced disorders.