Characterization of the Detection Module of the INSERT SPECT/MRI Clinical System

作者: M. Occhipinti , M. Carminati , P. Busca , A. D. Butt , G. L. Montagnani

DOI: 10.1109/TRPMS.2018.2864792

关键词:

摘要: Within the vast panorama of multimodal systems for clinical diagnosis, PET/MRI has been receiving significant attention. In parallel, new technological solutions have paving way to simultaneous SPECT/MRI systems, whose development so far delayed due challenging compatibility between MRI, gamma-ray detectors, and collimators. This paper presents an silicon photomultiplier (SiPM)-based Anger camera designed preclinical SPECT static inserts standard MR scanners. The detector is based on a continuous CsI(Tl) scintillator readout by arrays SiPMs custom ASICs. design adapted fit with limited space conditions (23 mm thickness), but also considering mutual issues. Despite these constraints thanks adoption iterative statistical event estimation method simply requiring flood image, maintains state-of-the-art performance in terms intrinsic spatial resolution (1.0 FWHM within usable field view) energy below 14% at 140 keV. experimental studies here performed show that camera, operate 0 °C reduce dark current SiPMs, can up 10 without worsening imaging performance.

参考文章(40)
Jamal Zweit, Philip R McDonagh, Gobalakrishnan Sundaresan, Celina Thadigiri, Vimalan Vijayaragavan, Likun Yang, David Hoffman, Minghao Sun, Frank Corwin, Narottam Lamichhane, Li Wang, Intrinsically radiolabelled [(59)Fe]-SPIONs for dual MRI/radionuclide detection. American journal of nuclear medicine and molecular imaging. ,vol. 4, pp. 548- 560 ,(2014)
Kirstin Jattke, Ralf Ladebeck, Wolfgang Renz, Matthias Schmand, Joe Camp, Volker Matschl, Matthew Martin, Lars Eriksson, Norbert Rietsch, Wolf-Dieter Heiss, Hubertus Fischer, Ron Grazioso, James Corbeil, Nan Zhang, Guenter Schnur, Ziad Burbar, Andrew Moor, Christian Michael, Bernard Bendriem, Lary Byars, BrainPET: First human tomograph for simultaneous (functional) PET and MR imaging Society of Nuclear Medicine Annual Meeting Abstracts. ,vol. 48, ,(2007)
Kevin Parnham, AbdEL-Monem El-Sharkawy, Andrew Rittenbach, Jingyan Xu, Benjamin Tsui, James Hugg, William Edelstein, A completed SPECT/MR insert for simultaneous SPECT/MR imaging of small animals The Journal of Nuclear Medicine. ,vol. 54, pp. 595- 595 ,(2013)
Rafael T. M. de Rosales, Potential clinical applications of bimodal PET-MRI or SPECT-MRI agents† Journal of Labelled Compounds and Radiopharmaceuticals. ,vol. 57, pp. 298- 303 ,(2014) , 10.1002/JLCR.3154
Debora Salvado, Kjell Erlandsson, Alexandre Bousse, Michele Occhipinti, Paolo Busca, Carlo Fiorini, Brian F. Hutton, Collimator Design for a Brain SPECT/MRI Insert IEEE Transactions on Nuclear Science. ,vol. 62, pp. 1716- 1724 ,(2015) , 10.1109/TNS.2015.2450017
Steven R Meikle, Peter Kench, Michael Kassiou, Richard B Banati, Small animal SPECT and its place in the matrix of molecular imaging technologies. Physics in Medicine and Biology. ,vol. 50, ,(2005) , 10.1088/0031-9155/50/22/R01
P Conde, AJ González, L Hernández, P Bellido, A Iborra, E Crespo, L Moliner, JP Rigla, María José Rodríguez-Álvarez, F Sánchez, Michael Seimetz, A Soriano, LF Vidal, JM Benlloch, None, Results of a combined monolithic crystal and an array of ASICs controlled SiPMs Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment. ,vol. 734, pp. 132- 136 ,(2014) , 10.1016/J.NIMA.2013.08.079
P. Busca, C. Fiorini, A.D. Butt, M. Occhipinti, R. Peloso, R. Quaglia, F. Schembari, P. Trigilio, G. Nemeth, P. Major, K. Erlandsson, B.F. Hutton, Simulation of the expected performance of INSERT: a new multi-modality SPECT/MRI system for preclinical and clinical imaging Nuclear Instruments & Methods in Physics Research Section A-accelerators Spectrometers Detectors and Associated Equipment. ,vol. 734, pp. 141- 146 ,(2014) , 10.1016/J.NIMA.2013.08.064
Seiichi Yamamoto, Tadashi Watabe, Yasukazu Kanai, Hiroshi Watabe, Jun Hatazawa, Development of an Optical Fiber-Based MR Compatible Gamma Camera for SPECT/MRI Systems IEEE Transactions on Nuclear Science. ,vol. 62, pp. 76- 81 ,(2015) , 10.1109/TNS.2014.2387432
F. Neves, V. Solovov, V. Chepel, M.I. Lopes, J. Pinto da Cunha, A. Lindote, C. Silva, Position reconstruction in a liquid xenon scintillation chamber for low-energy nuclear recoils and γ-rays Nuclear Instruments & Methods in Physics Research Section A-accelerators Spectrometers Detectors and Associated Equipment. ,vol. 573, pp. 48- 52 ,(2007) , 10.1016/J.NIMA.2006.10.390