Novel minimal physiologically-based model for the prediction of passive tubular reabsorption and renal excretion clearance
作者： Daniel Scotcher , Christopher Jones , Amin Rostami-Hodjegan , Aleksandra Galetin
DOI: 10.1016/J.EJPS.2016.03.018
关键词:
摘要: Purpose Develop a minimal mechanistic model based on in vitro–in vivo extrapolation (IVIVE) principles to predict extent of passive tubular reabsorption. Assess the ability developed reabsorption (Freab) and renal excretion clearance (CLR) from vitro permeability data physiological parameters.
core.ac.uk
manchester.ac.uk参考文章(77)
Graham Rd Jones, Estimating renal function for drug dosing decisions. The Clinical biochemist. Reviews / Australian Association of Clinical Biochemists. ,vol. 32, pp. 81- 88 ,(2011)
John J. Pahira, William C. Maxted, Jeff A. Simerville, Urinalysis: A Comprehensive Review American Family Physician. ,vol. 71, pp. 1153- 1162 ,(2005)
Swati Nagar, Upendra A. Argikar, Donald J. Tweedie, Enzyme Kinetics in Drug Metabolism: Fundamentals and Applications Methods in Molecular Biology. ,vol. 1113, pp. 1- 6 ,(2014) , 10.1007/978-1-62703-758-7_1
Aleksandra Galetin, Rationalizing Underprediction of Drug Clearance from Enzyme and Transporter Kinetic Data: From In Vitro Tools to Mechanistic Modeling Methods in Molecular Biology. ,vol. 1113, pp. 255- 288 ,(2014) , 10.1007/978-1-62703-758-7_13
Rutwij A. Dave, Marilyn E. Morris, Semi-mechanistic kidney model incorporating physiologically-relevant fluid reabsorption and transporter-mediated renal reabsorption: pharmacokinetics of γ-hydroxybutyric acid and l -lactate in rats Journal of Pharmacokinetics and Pharmacodynamics. ,vol. 42, pp. 497- 513 ,(2015) , 10.1007/S10928-015-9441-1
Manthena V. Varma, Stefanus J. Steyn, Charlotte Allerton, Ayman F. El-Kattan, Predicting Clearance Mechanism in Drug Discovery: Extended Clearance Classification System (ECCS). Pharmaceutical Research. ,vol. 32, pp. 3785- 3802 ,(2015) , 10.1007/S11095-015-1749-4
B. B. Taylor, T. G. Donald, Impaired doctors: the Royal Australasian College of Physicians' support for Fellows in difficulty. Internal Medicine Journal. ,vol. 45, pp. 466- 466 ,(2015) , 10.1111/IMJ.12717
M Rowland, S Hall, Relationship between renal clearance, protein binding and urine flow for digitoxin, a compound of low clearance in the isolated perfused rat kidney. Journal of Pharmacology and Experimental Therapeutics. ,vol. 228, pp. 174- 179 ,(1984)
Andrés Olivares-Morales, Hans Lennernäs, Leon Aarons, Amin Rostami-Hodjegan, Translating Human Effective Jejunal Intestinal Permeability to Surface-Dependent Intrinsic Permeability: a Pragmatic Method for a More Mechanistic Prediction of Regional Oral Drug Absorption Aaps Journal. ,vol. 17, pp. 1177- 1192 ,(2015) , 10.1208/S12248-015-9758-0
Maki Hasegawa, Hiroyuki Kusuhara, Hitoshi Endou, Yuichi Sugiyama, Contribution of Organic Anion Transporters to the Renal Uptake of Anionic Compounds and Nucleoside Derivatives in Rat Journal of Pharmacology and Experimental Therapeutics. ,vol. 305, pp. 1087- 1097 ,(2003) , 10.1124/JPET.102.046847