Neural Progenitors in the Developing Neocortex of the Northern Tree Shrew (Tupaia belangeri) Show a Closer Relationship to Gyrencephalic Primates Than to Lissencephalic Rodents.

摘要: The neocortex is the most complex part of mammalian brain and as such it has undergone tremendous expansion during evolution, especially in primates. majority neocortical neurons originate from distinct neural stem progenitor cells (NPCs) located ventricular subventricular zone (SVZ). Previous studies revealed that SVZ thickness well abundance distribution NPCs, basal radial glia (bRG), differ markedly between lissencephalic rodent gyrencephalic primate neocortex. northern tree shrew (Tupaia belangeri) a rat-sized mammal with high to body mass ratio, which stands phylogenetically mid-way rodents Our study provides - for first time detailed data on presence, bRG other NPCs developing belangeri). We show characterized by an expanded SVZ, Pax6+ relatively percentage at peak upper-layer neurogenesis. further demonstrate key features development, e.g., are closer related those primates than ferret rodents. Together, our novel insight into evolution development Euarchontoglires introduces potential model organism area human developmental disorders.