Ginkwanghols A and B, osteogenic coumaric acid-aliphatic alcohol hybrids from the leaves of Ginkgo biloba.

作者: Seon-Hee Kim , Yoon-Joo Ko , Jae Sik Yu , Kwang Ho Lee , Ki Hyun Kim

DOI: 10.1007/S12272-021-01329-3

关键词:

摘要: Ginkgo biloba (Ginkgoaceae), commonly known as "ginkgo", is called a living fossil, and it has been cultivated early in human history for various uses traditional medicine source of food. As part ongoing research to explore the chemical diversity biologically active compounds from natural resources, two new coumaric acid-aliphatic alcohol hybrids, ginkwanghols A (1) B (2) were isolated leaves G. biloba. The hybrids products have rarely reported. structures determined by extensive NMR spectroscopic analysis, HRESI-MS, quantum ECD calculations, comparing experimental HRESI-MS/MS spectrum chemically transformed compound 1a with predicted spectra proposed CFM-ID 3.0, software tool MS/MS spectral prediction MS-based identification. Ginkwanghols increased alkaline phosphatase (ALP) production C3H10T1/2, mouse mesenchymal stem cell line, dose-dependent manner. In addition, mediated promotion osteogenic differentiation indicated induction mRNA expression markers ALP osteopontin (OPN).

参考文章(34)
R.B. Hallworth, Prevention and Treatment of Postmenopausal Osteoporosis Pharmacy World & Science. ,vol. 20, pp. 198- 205 ,(1998) , 10.1023/A:1008682921480
Hiroshi Goto, Toyonobu Usuki, 1H‐NMR Analysis of Terpene Trilactones (TTLs) in Ginkgo biloba: Green Female Leaves Contain the Most TTLs Phytochemical Analysis. ,vol. 23, pp. 84- 87 ,(2012) , 10.1002/PCA.1328
James R Vyvyan, Donald L. Pavia, Gary M. Lampman, George S. Kriz, Introduction to spectroscopy Cengage Learning. pp. 1- ,(2015)
TAICHI OHMOTO, KEEKO KANATANI (née INAGAKI), KYOKO YAMAGUCHI, Constituent of pollen. XIII Constituents of Cedrus deodara Loud. (2) Chemical & Pharmaceutical Bulletin. ,vol. 35, pp. 229- 234 ,(1987) , 10.1248/CPB.35.229
Paul F. Smith, Karyn Maclennan, Cynthia L. Darlington, The neuroprotective properties of the Ginkgo biloba leaf: a review of the possible relationship to platelet-activating factor (PAF) Journal of Ethnopharmacology. ,vol. 50, pp. 131- 139 ,(1996) , 10.1016/0378-8741(96)01379-7
Basil Danylec, Magdy N. Iskander, 1h nmr measurement of the trans-cis photoisomerization of cinnamic acid derivatives Journal of Chemical Education. ,vol. 79, pp. 1000- 1001 ,(2002) , 10.1021/ED079P1000
Ritu Trivedi, Avinash Kumar, Varsha Gupta, Sudhir Kumar, Geet. K. Nagar, Jose R. Romero, Anil Kumar Dwivedi, Naibedya Chattopadhyay, Effects of Egb 761 on bone mineral density, bone microstructure, and osteoblast function: Possible roles of quercetin and kaempferol. Molecular and Cellular Endocrinology. ,vol. 302, pp. 86- 91 ,(2009) , 10.1016/J.MCE.2009.01.011