Taxoids, their preparation and pharmaceutical compositions containing them

作者: Alain Commercon , Herve Bouchard , Jean Dominique Bourzat

DOI:

关键词:

摘要: Novel taxoids of general formula (I), the preparation thereof and pharmaceutical compositions containing same, are disclosed. In Z is a hydrogen atom or radical (II), wherein R1 an optionally substituted benzoyl R2-O-CO-, where R2 alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, bicycloalkyl, phenyl heterocyclyl radical; R3 phenyl, naphthyl aromatic heterocyclic R4 hydroxy alkoxy, alkenyloxy, alkynyloxy, alkanoyloxy, alkenoyloxy, alkoxyacetyl alkyloxycarbonyloxy radical, cycloalkyloxy, cycloalkenyloxy, arylcarbonyloxy heterocyclylcarbonyloxy R5 alkoxy cycloalkyloxy cycloalkenyloxy radical. The novel compounds have remarkable antitumoral antineoplastic properties.

参考文章(109)
O S Selawry, F M Muggia, M H Cohen, P J Creaven, H H Hansen, Phase I clinical trial of weekly and daily treatment with camptothecin (NSC-100880): correlation with preclinical studies. Cancer chemotherapy reports. ,vol. 56, pp. 515- 521 ,(1972)
Shu-Hui Chen, Vittorio Farina, 7,8-cyclopropataxanes ,(1993)
Nicholas Schulz, Ira Daar, George F. Van Woude, Renping Zhou, Marianne Oskarsson, Method for designing cancer treatment regimens and methods and pharmaceutical compositions for the treatment of cancer ,(1992)
Andre Durand, Rodolphe Margraff, Alain Gerbaud, Process for the purification of taxoids. ,(1994)
Anne Monks, Han-Mo Koo, George F. Vande Woude, Methods of identifying drugs with selective effects against cancer cells ,(1994)
Yukio East Paul Dirac Drive Suzuki, Robert A. East Paul Dirac Drive Holton, Seocchan East Paul Dirac Drive Kim, Process for the preparation of baccatin iii analogs bearing new c2 and c4 functional groups ,(1994)
Shigeki Imafuku, Noriaki Yoshida, Takeshi Takeda, Takashi Shimizu, Parts supplying method in which movements of parallel supply tables are controlled ,(1992)
Stanley T. Crooke, Francis L. McCabe, Randall K. Johnson, Leo F. Faucette, Chiu-Mei Sung, Christopher K. Mirabelli, A Murine Model to Evaluate the Ability of in Vitro Clonogenic Assays to Predict the Response to Tumors in Vivo Cancer Research. ,vol. 48, pp. 5447- 5454 ,(1988)
Peter G. M. Wuts, Theodora W. Greene, Protective groups in organic synthesis ,(1981)