作者: Alain Commercon , Herve Bouchard , Jean Dominique Bourzat
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摘要: Novel taxoids of general formula (I), the preparation thereof and pharmaceutical compositions containing same, are disclosed. In Z is a hydrogen atom or radical (II), wherein R1 an optionally substituted benzoyl R2-O-CO-, where R2 alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, bicycloalkyl, phenyl heterocyclyl radical; R3 phenyl, naphthyl aromatic heterocyclic R4 hydroxy alkoxy, alkenyloxy, alkynyloxy, alkanoyloxy, alkenoyloxy, alkoxyacetyl alkyloxycarbonyloxy radical, cycloalkyloxy, cycloalkenyloxy, arylcarbonyloxy heterocyclylcarbonyloxy R5 alkoxy cycloalkyloxy cycloalkenyloxy radical. The novel compounds have remarkable antitumoral antineoplastic properties.