Comparative modelling: an essential methodology for protein structure prediction in the post-genomic era.

摘要: The gap between the number of protein sequences and structures is increasing rapidly, exacerbated by completion numerous genome projects now flooding into public databases. To fill this gap, comparative modelling widely considered most accurate technique for predicting three-dimensional shape proteins. High-throughput, automatic should considerably increase our access to other than those determined experimental techniques such as X-ray crystallography NMR (nuclear magnetic resonance) spectroscopy. uses these complete models are growing ranging from guiding site-directed mutagenesis experiments protein-protein interaction predictions. In recognition this, a very useful servers have begun emerge on Web. Molecular biologists powerful web-based toolkit construct models, assess their accuracy, use them explain predict experiments. There is, however, still much do engaged in algorithmic development if compete an equal footing with structure determination techniques.