CD24, a signal transducer modulating B cell activation responses, is a very short peptide with a glycosyl phosphatidylinositol membrane anchor.

摘要: CD24 is a signal-transducing molecule on the surfaces of most human B cells that can modulate their response to activation signals by antagonizing IL-induced differentiation into antibody-forming and inducing proliferation in combination with generated Ag receptors. A cDNA directs expression transfected COS was cloned its homology encoding murine M1/69-J11d heat stable Ag. The encodes mature peptide only 31 35 amino acids extensively glycosylated attached outer surface plasma membrane glycosyl phosphatidylinositol lipid anchor. Although structurally similar M1/69-J11d, two appear have common genetic ancestry, confined small cluster comprising potential N-linked glycosylation sites. Combined differences patterns Ag, this indicates may not equivalent functional roles lymphoid development. novel structure suggests signaling could be triggered binding lectin-like ligand carbohydrates projecting from peptide, transduced through release second messengers derived anchor CD24.