The role of cytokines in the regulation of drug disposition: extended functional pleiotropism?

摘要: Introduction: Drug disposition, metabolism and drug–drug interactions are important considerations for most drugs. Cytokines integral to the successful resolution of many diseases. Data emerging on a role cytokines in regulation expression activity drug transporters metabolising enzymes. Investigation interaction between pharmacological immunological responses is key understanding complex relationships involved patient response therapy. Areas covered: Evidence detailing ability regulate disposition reviewed context different cell tissue types. The literature search undertaken provides an overview current interrelationship factors which may influence Expert opinion: Dysregulation cytokine networks hallmark number diseases such as HIV cancer. mechanisms by ...