Voxel‐based morphometry for separation of schizophrenia from other types of psychosis in first‐episode psychosis

摘要: Background Schizophrenia is a psychiatric disorder which involves distortions in thought and perception, blunted affect, behavioural disturbances. The longer psychosis goes unnoticed untreated, the more severe repercussions for relapse recovery. There some evidence that early intervention services can help, diagnostic techniques could contribute to may offer clinical utility these situations. index test being evaluated this review structural magnetic resonance imaging (MRI) analysis technique known as voxel-based morphometry (VBM) estimates distribution of grey matter tissue volume across several brain regions. This an exploratory examination ‘potential’ VBM use additional tool patients with first episode establish whether individual will progress on developing schizophrenia opposed other types psychosis. Objectives To determine applied be used differentiate from participants who have received diagnosis psychosis. Search methods In December 2013, we updated previous search (May 2012) MEDLINE, EMBASE, PsycInfo using OvidSP. Selection criteria We included retrospective prospective studies consecutively or randomly selected adolescent adult (< 45 years) psychosis; accuracy differentiating psychoses compared made by qualified mental health professional, without standard operational criteria symptom checklists. We excluded children, organic disorders were at high risk schizophrenia, such people genetic predisposition. Data collection analysis Two authors screened all references inclusion. assessed quality QUADAS-2 instrument. Due lack data, not able extract 2 x data tables each study nor undertake any meta-analysis. Main results We four total 275 psychosis. was diagnose studies, instead quantify magnitude differences volume. Therefore, none reported analysis, summarised findings narratively study. Authors' conclusions There no currently support diagnosing (as psychotic disorders) pattern changes seen has potential discriminate between categories but methods do reliably are evolution. In addition, applicability practice date limits usefulness aid presentations