Control-layer optimization for flow-based mVLSI microfluidic biochips

摘要: Recent advantages in flow-based microfluidic biochips have enabled the emergence of lab-on-a-chip devices for bimolecular recognition and point-of-care disease diagnostics. However, adoption is hampered today by lack computer-aided design tools. Manual procedures not only delay product development but they also inhibit exploitation complexity that possible with current fabrication techniques. In this paper, we present first practical problem formulation automated control-layer VLSI (mVLSI) propose a systematic approach solving problem. Our goal to find an efficient routing solution minimum number control pins. The pressure-propagation delay, intrinsic physical phenomenon mVLSI biochips, minimized order reduce response time valves, decrease pattern set-up time, synchronize valve actuation. Two fabricated five synthetic benchmarks are used evaluate proposed optimization method. Compared manual baseline approach, leads fewer pins, better timing behavior, shorter channel length layer.