Role of ERK1/ERK2 and p70S6K pathway in insulin signalling of protein synthesis.
作者： Elizabeth M. Sale , Peter P.G. Atkinson , Caroline H. Arnott , John E. Chad , Graham J. Sale
DOI: 10.1016/S0014-5793(99)00193-3
关键词:
摘要: The signalling pathways by which insulin triggers protein synthesis were studied using an antisense strategy to deplete ERK1/ERK2 and rapamycin inhibit the p70S6K pathway. results indicated that principally regulated amount of machinery available in cell while pathway contributed modulating its activation response insulin. also mediated a small proportion insulin-stimulated included induction c-fos protein. When was blocked majority still occurred thus did not require transcriptional regulation or targets.
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