Differential expression of alpha and beta thyroid hormone receptor genes in rat brain and pituitary.

摘要: Multiple thyroid hormone receptor cDNAs have previously been identified in rat and are classified into alpha beta subtypes. Alternative splicing of the gene gives rise to functional receptor, rTR 1, non-thyroid hormone-binding isotype, 2. Recent evidence suggests encodes two receptors, pituitary-specific By using synthetic DNA probes common transcripts specific for 1 2 mRNAs, we mapped expression these adult brain pituitary by hybridization histochemistry. We also localized mRNAs encoding putative nuclear REV-ErbA alpha, a portion which is derived from opposite strand gene. were widely distributed similar, if not identical, pattern. Highest levels found olfactory bulb, hippocampus, granular layer cerebellar cortex. more restricted patterns distinct those mRNA was highest neocortex. High anterior parvocellular part paraventricular hypothalamic nucleus suggest products may mediate feedback regulation thyroid-stimulating thyrotropin-releasing hormone. Our results identify nuclei structures mammalian central nervous system subtypes occur.