Surface mechanics mediate pattern formation in the developing retina

摘要: Pattern formation of biological structures involves organizing different types cells into a spatial configuration. In this study, we investigate the physical basis patterning Drosophila retina in vivo. We demonstrate that E- and N-cadherins mediate apical adhesion between epithelial cells. Differential expression N-cadherin within sub-group retinal (cone cells) causes them to form an overall shape minimizes their surface contact with surrounding The group, both normal experimentally manipulated conditions, pack together same way as soap bubbles do. shaping cone cell group packing its components precisely imitate tendency for surfaces be minimized. Thus, simple patterned results complex pattern owing cellular mechanics.