The role of nucleoside transporters in cancer chemotherapy with nucleoside drugs

摘要: Nucleoside analogs are important components of treatment regimens for various malignancies. Nucleoside-specific membrane transporters mediate plasma permeation physiologic nucleosides and most nucleoside analogs, which the initial event is cellular conversion to active agents. Understanding roles in drug toxicity resistance will provide opportunities potentiating anticancer efficacy avoiding resistance. Because transportability a possible determinant many transporter abundance might be prognostic marker assess Elucidation structural determinants interaction with proteins as well features required permeant translocation lead “transportability guidelines” rational design therapeutic application drugs. It should eventually develop clinical assays that predict sensitivity and/or anti-cancer drugs thus identify those patient populations likely benefit from optimal analog treatments. This review discusses recent results structure/function studies human transporters, role transport processes cytotoxicity several strategies improve transporter-related effects analogs.