作者: EI Agaba , GC Asobie , P Enokela , SA Ogli
DOI: 10.4314/HMRJ.V15I1
关键词:
摘要: Background : The study was designed to investigate renal function profile upon exposure graded oral doses of Di (2- ethylhexyl) phthalate (DEHP) in the adult Wistar rats considering that DEHP leaches easily from plastic foods, drinking water and environment Methods Twenty (20) rats were administered in the 0.02mg/kg, 20mg/kg 200mg/kg body weight in blocks A, B C respectively through intrapharyngeal route. Rats block D, serving as control, administered distill water. Both treatments distilled were administered at a convenient dose 0.1ml over 30 day duration. Serum obtained each rat analyzed for electrolytes (Na + , K Cl - ), creatinine urea Results Oral graded doses used this increased only mean serum urea from 32.6 ± 2.63 mg/dl control 42.01 3.05 mg/dl, 41.75 ± 1.93 40.2 2.82 treated with 0.02mg, 20mg 200mg DEHP/body weight respectively. Other parameters Na remain unchanged. Conclusion Exposure induced an elevation of the blood nitrogen irrespective without affecting serum electrolytes Keywords (2-ethylhexyl) phthalate, DEHP, Renal function, Plasticizer, Azotaemia