Effects of Prolonged High Phosphorus Diet on Phosphorus and Calcium Balance in Rats
作者： Yoshiko Tani , Tadatoshi Sato , Hisami Yamanaka-Okumura , Hironori Yamamoto , Hidekazu Arai
DOI: 10.3164/JCBN.40.221
关键词:
摘要: The amount of phosphorus contained in food as additives is currently increasing and a high intake can cause various diseases. To determine the effects prolonged diet, here we investigated calcium balance expression type IIa sodium-dependent phosphate transporter (Npt IIa) mature rats. Wistar male rats (8-weeks old) were divided into five groups fed diets containing 0.6% plus 0.3, 0.6, 0.9, 1.2 or 1.5% for 4 weeks. Urinary fecal excretions significantly increased by (from 0.6 to 1.5%), dependent on dietary phosphorus. net absorption intestinal was also diets. As result, negative observed given 1.2% Serum parathyroid hormone 1,25-dihydroxyvitamin D3 concentrations In addition, decreased Npt mRNA protein renal brush border membrane. Taken together, these results suggest that have potentially adverse homeostasis rat.
researchgate.net 
sci-hub.se 参考文章(42)
B. G. Shah, J. C. Meranger, Effect of increased dietary phosphorus on calcium metabolism of young rats Canadian Journal of Physiology and Pharmacology. ,vol. 48, pp. 675- 680 ,(1970) , 10.1139/Y70-099
B. G. Shah, G. V. G. Krishnarao, H. H. Draper, The relationship of Ca and P nutrition during adult life and osteoporosis in aged mice. Journal of Nutrition. ,vol. 92, pp. 30- 42 ,(1967) , 10.1093/JN/92.1.30
H. H. Draper, Ten-Lin Sie, J. G. Bergan, Osteoporosis in Aging Rats Induced by High Phosphorus Diets The Journal of Nutrition. ,vol. 102, pp. 1133- 1141 ,(1972) , 10.1093/JN/102.9.1133
Ten-Lin Sie, H. H. Draper, R. Raines Bell, Hypocalcemia, Hyperparathyroidism and Bone Resorption in Rats Induced by Dietary Phosphate Journal of Nutrition. ,vol. 104, pp. 1195- 1201 ,(1974) , 10.1093/JN/104.9.1195
Charlotte M. Young, Elizabeth L. Empey, Don Turk, Virginia U. Serraon, Experimental obesity and weight reduction in young female rats: development of procedures and calcium and phosphorus balance studies. Journal of Nutrition. ,vol. 70, pp. 353- 360 ,(1960) , 10.1093/JN/70.3.353
Mona S. Calvo, The Effects of High Phosphorus Intake on Calcium Homeostasis Advances in Nutritional Research. ,vol. 9, pp. 183- 207 ,(1994) , 10.1007/978-1-4757-9092-4_11
Philip G. Reeves, Forrest H. Nielsen, George C. Fahey, AIN-93 Purified Diets for Laboratory Rodents: Final Report of the American Institute of Nutrition Ad Hoc Writing Committee on the Reformulation of the AIN-76A Rodent Diet Journal of Nutrition. ,vol. 123, pp. 1939- 1951 ,(1993) , 10.1093/JN/123.11.1939
Mona S. Calvo, Youngmee K. Park, Changing phosphorus content of the U.S. diet: potential for adverse effects on bone. Journal of Nutrition. ,vol. 126, ,(1996) , 10.1093/JN/126.SUPPL_4.1168S
Juliette C. Howe, Gary R. Beecher, Effect of dietary protein and phosphorus levels on calcium and phosphorus metabolism of the young, fast growing rat. Journal of Nutrition. ,vol. 111, pp. 708- 720 ,(1981) , 10.1093/JN/111.4.708
Fumie TAKAHASHI, Kyoko MORITA, Kanako KATAI, Hiroko SEGAWA, Ai FUJIOKA, Tomoko KOUDA, Sawako TATSUMI, Tomoko NII, Yutaka TAKETANI, Hiromi HAGA, Setsuji HISANO, Yoshihiro FUKUI, Ken-ichi MIYAMOTO, Eiji TAKEDA, Effects of dietary Pi on the renal Na+-dependent Pi transporter NaPi-2 in thyroparathyroidectomized rats Biochemical Journal. ,vol. 333, pp. 175- 181 ,(1998) , 10.1042/BJ3330175