GNPS-guided discovery of xylacremolide C and D, evaluation of their putative biosynthetic origin and bioactivity studies of xylacremolide A and B.
作者： Tanja Schirmeister , Christine Beemelmanns , Thorsten Heinzel , Michael Poulsen , Soohyun Um
DOI: 10.1039/D1RA00997D
关键词:
摘要: Targeted HRMS2-GNPS-based metabolomic analysis of Pseudoxylaria sp. X187, a fungal antagonist the fungus-growing termite symbiosis, resulted in identification two lipopeptidic congeners xylacremolides, named xylacremolide C and D, which are built from d-phenylalanine, l-proline an acetyl-CoA starter unit elongated by four malonyl-CoA derived ketide units. The putative xya gene cluster was identified draft genome generated Illumina PacBio sequencing RNAseq studies. Biological activities A B were evaluated revealed weak histone deacetylase inhibitory (HDACi) antifungal activities, as well moderate protease inhibition activity across panel nine human, viral bacterial proteases.
rsc.org
sci-hub.st 参考文章(48)
Stephan Duss, Heike Brinkhaus, Adrian Britschgi, Erik Cabuy, Daniel M Frey, Dirk J Schaefer, Mohamed Bentires-Alj, Mesenchymal precursor cells maintain the differentiation and proliferation potentials of breast epithelial cells Breast Cancer Research. ,vol. 16, pp. 1- 16 ,(2014) , 10.1186/BCR3673
Patricia S. Doyle, Yuan M. Zhou, Ivy Hsieh, Doron C. Greenbaum, James H. McKerrow, Juan C. Engel, The Trypanosoma cruzi Protease Cruzain Mediates Immune Evasion PLoS Pathogens. ,vol. 7, pp. e1002139- ,(2011) , 10.1371/JOURNAL.PPAT.1002139
Ranjala Ratnayake, Leith J. Fremlin, Ernest Lacey, Jennifer H. Gill, Robert J. Capon, Acremolides A-D, lipodepsipeptides from an Australian marine-derived fungus, Acremonium sp Journal of Natural Products. ,vol. 71, pp. 403- 408 ,(2008) , 10.1021/NP070589G
Maria Cândida Monteiro, Mercedes de la Cruz, Juan Cantizani, Catalina Moreno, José R. Tormo, Emilia Mellado, J. Ramón De Lucas, Francisco Asensio, Vito Valiante, Axel A. Brakhage, Jean-Paul Latgé, Olga Genilloud, Francisca Vicente, A New Approach to Drug Discovery: High-Throughput Screening of Microbial Natural Extracts against Aspergillus fumigatus Using Resazurin Journal of Biomolecular Screening. ,vol. 17, pp. 542- 549 ,(2012) , 10.1177/1087057111433459
S. K. Mazmanian, G. Liu, E. R. Jensen, E. Lenoy, O. Schneewind, Staphylococcus aureus sortase mutants defective in the display of surface proteins and in the pathogenesis of animal infections. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 97, pp. 5510- 5515 ,(2000) , 10.1073/PNAS.080520697
Manfred Gareis, Christoph Gottschalk, Stachybotrys spp. and the guttation phenomenon. Mycotoxin Research. ,vol. 30, pp. 151- 159 ,(2014) , 10.1007/S12550-014-0193-3
Benjamin P Howden, Christopher RE McEvoy, David L Allen, Kyra Chua, Wei Gao, Paul F Harrison, Jan Bell, Geoffrey Coombs, Vicki Bennett-Wood, Jessica L Porter, Roy Robins-Browne, John K Davies, Torsten Seemann, Timothy P Stinear, None, Evolution of multidrug resistance during Staphylococcus aureus infection involves mutation of the essential two component regulator WalKR. PLOS Pathogens. ,vol. 7, pp. 1- 15 ,(2011) , 10.1371/JOURNAL.PPAT.1002359
Fei Song, Shao-Hua Wu, Ying-Zhe Zhai, Qi-Cun Xuan, Tang Wang, Secondary Metabolites from the Genus Xylaria and Their Bioactivities Chemistry & Biodiversity. ,vol. 11, pp. 673- 694 ,(2014) , 10.1002/CBDV.201200286
Mikael Djurfeldt, Anders Lansner, 1st INCF Workshop on Large-scale Modeling of the Nervous System F1000Research. ,vol. 7, pp. 1- 1 ,(2007) , 10.1038/NPRE.2007.262.1
Michael Poulsen, Haofu Hu, Cai Li, Zhensheng Chen, Luohao Xu, Saria Otani, Sanne Nygaard, Tania Nobre, Sylvia Klaubauf, Philipp M. Schindler, Frank Hauser, Hailin Pan, Zhikai Yang, Anton S. M. Sonnenberg, Z. Wilhelm de Beer, Yong Zhang, Michael J. Wingfield, Cornelis J. P. Grimmelikhuijzen, Ronald P. de Vries, Judith Korb, Duur K. Aanen, Jun Wang, Jacobus J. Boomsma, Guojie Zhang, Complementary symbiont contributions to plant decomposition in a fungus-farming termite Proceedings of the National Academy of Sciences of the United States of America. ,vol. 111, pp. 14500- 14505 ,(2014) , 10.1073/PNAS.1319718111