The effect of chronic L-DOPA administration on supersensitive pre- and postsynaptic dopaminergic receptors in rat brain
作者： Avinoam Reches , H.Ryan Wagner , De-hua Jiang , Vernice Jackson , Stanley Fahn
DOI: 10.1016/0024-3205(82)90398-8
关键词:
摘要: Chronic administration of haloperidol induced supersensitivity the pre- and postsynaptic dopaminergic receptors in rat brain. The response presynaptic was determined by an enhanced inhibitory effect apomorphine on dopamine synthesis after gamma-butyrolactone injection. This change receptor function detected both nigrostriatal mesolimbic pathways. Haloperidol also increased 3H-spiperone binding sites striatal membranes, indicating receptors. Subsequent prolonged treatment with high doses L-DOPA/carbidopa resulted a decrease sites, but had no supersensitive It is suggested that tardive dyskinesia may be state chronic L-DOPA have differential these sites.
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sci-hub.se 参考文章(36)
Robert H. Roth, Martha C. Nowycky, Presynaptic dopamine receptors. Development of supersensitivity following treatment with fluphenazine decanoate. Naunyn-schmiedebergs Archives of Pharmacology. ,vol. 300, pp. 247- 254 ,(1977) , 10.1007/BF00500967
A. Lewis Farr, Oliver H. Lowry, Rose J. Randall, Nira J. Rosebrough, Protein Measurement with the Folin Phenol Reagent Journal of Biological Chemistry. ,vol. 193, pp. 265- 275 ,(1951)
Thomas F. Seeger, Eliot L. Gardner, Wagner F. Bridger, Increase in mesolimbic electrical self-stimulation after chronic haloperidol: reversal by L-DOPA or lithium Brain Research. ,vol. 215, pp. 404- 409 ,(1981) , 10.1016/0006-8993(81)90525-4
George G. Yarbrough, Supersensitivity of caudate neurones after repeated administration of haloperidol. European Journal of Pharmacology. ,vol. 31, pp. 367- 369 ,(1975) , 10.1016/0014-2999(75)90062-X
J. I. NAGY, T. LEE, P. SEEMAN, H. C. FIBIGER, Direct evidence for presynaptic and postsynaptic dopamine receptors in brain Nature. ,vol. 274, pp. 278- 281 ,(1978) , 10.1038/274278A0
Cheryl Ezrin-Waters, Philip Seeman, L-DOPA reversal of hyperdopaminergic behaviour Life Sciences. ,vol. 22, pp. 1027- 1031 ,(1978) , 10.1016/0024-3205(78)90271-0
D. Burt, I Creese, S. Snyder, Antischizophrenic drugs: chronic treatment elevates dopamine receptor binding in brain Science. ,vol. 196, pp. 326- 328 ,(1977) , 10.1126/SCIENCE.847477
DOROTHY W. GALLAGER, AGU PERT, WILLIAM E. BUNNEY, Haloperidol-induced presynaptic dopamine supersensitivity is blocked by chronic lithium Nature. ,vol. 273, pp. 309- 312 ,(1978) , 10.1038/273309A0
Judith R. Walters, Robert H. Roth, Dopaminergic neurons: An in vivo system for measuring drug interactions with presynaptic receptors Naunyn-schmiedebergs Archives of Pharmacology. ,vol. 296, pp. 5- 14 ,(1976) , 10.1007/BF00498834
L.E. Roel, P. Levine, D. Rubin, D. Markovitz, H.N. Munro, R.J. Wurtman, Effect of L-DOPA pretreatment on protein synthesis in various rat brain regions Life Sciences. ,vol. 22, pp. 1887- 1891 ,(1978) , 10.1016/0024-3205(78)90475-7