Effect of Jun N-terminal kinase 1 and 2 on the replication of Penicillium marneffei in human macrophages.
作者： Renqiong Chen , Liyan Xi , Xiaowen Huang , Tuan Ma , Hong Ren
DOI: 10.1016/J.MICPATH.2015.03.014
关键词:
摘要: Penicillium marneffei (P. marneffei) is a human pathogen which persists in macrophages and threatens the immunocompromised patients. To clarify mechanisms involved, we evaluated effect of c-Jun N-terminal kinase 1 2 (JNK1/2) on cytokine expression, phagosomal maturation multiplication P. marneffei-stimulated macrophages. induced rapid phosphorylation JNK1/2. Using specific inhibitor JNK1/2 (SP600125), found that inhibition suppressed marneffei-induced tumor necrosis factor-α IL-10 production. In addition, presence SP600125 increased acidification decreased intracellular replication. These data suggest may play an important role promoting replication marneffei. Our findings further indicate through pathway attenuate immune response macrophage antifungal function.
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