Spontaneous intestinal adenocarcinoma in geriatric macaques (Macaca sp.).

摘要: BACKGROUND AND PURPOSE Intestinal adenocarcinoma appears to be the most common malignant neoplasm in macaques, and is a substantial cause of morbidity mortality elderly. METHODS A retrospective review 32 cases was done. RESULTS Thirty-two were reviewed. Clinical examination had revealed severe weight loss, anorexia, palpable abdominal mass. Microcytic hypochromic anemia, intermittent fecal occult blood positive test results, hypoproteinemia, hypoalbuminemia predominant clinical laboratory findings. Carcinoembryogenic antigen serologic testing single-strand conformational polymorphism analysis performed selected cases. The sites intestinal ileocecal junction, colon, ileum, jejunum, cecum. Metastases evident 34% involved peripheral nodes, liver, lungs, pancreas, adrenal gland. Overall survival 12 macaques that underwent surgical excision 83% at 6 months, 58% 1 year, 50% 1.5 years, 33% 2 8% 4 years. overall mean rate (MSR) > 483 postoperative days. CONCLUSION adenocarcinomas should amenable resection. Early detection localized, non-invasive neoplasms will increase cure rate. Survivability could potentially improved by use adjuvant therapies.