Towards a validation of atlas warping techniques

摘要: Abstract Pre-operative magnetic resonance (MRI) and computed tomography (CT) image volumes are often used for planning guidance during functional neurosurgical procedures. These operations can include the creation of lesions in thalamus (thalamotomy) or globus pallidus (pallidotomy), insertion deep brain stimulation (DBS) electrodes subcortical nuclei. targets difficult to localize pre-operative imaging data due limited resolution contrast available standard MRI CT techniques. To address this problem, digital atlases nuclei accurately identify surgical since they be warped fit each patient’s unique anatomy. Targeting accuracy thus depends on quality atlas-to-patient warp. In paper, three warping techniques compared. Two methods rely an template as intermediary estimate a nonlinear transformation. The third is novel, uses pseudo-MRI derived from atlas basal ganglia transformation directly. compared using (1) manual segmentations (2) intra-operative thalamic stimulation. results demonstrate that template-based technique best customizing onto patient data.