Non-nucleoside linkers for convenient attachment of labels to oligonucleotides using standard synthetic methods

摘要: Pseudonucleosides and pseudonucleotides are useful in the synthesis of oligomers which contain these components as a means to derivatize resulting oligonucleotide substituents such chelators, intercalators, or lipophilic compounds. In general, pseudonucleotide formula: ##STR1## wherein each Y is independently O S; X H, PO 3 -2 , an activated nucleotide coupling moiety, protecting group, nucleoside, sequence, comprises solid support; F functional group capable linking additional moiety said already reacted effect binding moiety; □ organic backbone does not Y-X either achiral even when different, single enantiomer chiral compound; with proviso that at least one nucleotide, support, represents group. Oligonucleotides having pseudonucleoside 3' terminus particularly stable vivo.