Hydroxyl Group‐Assisted Palladium‐Catalyzed Lactonization of Homoallylic Alcohols
作者： Liangbin Huang , Qian Wang , Wanqing Wu , Huanfeng Jiang
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摘要: A convenient and highly efficient synthesis of α-methylene-γ-lactones through the palladium(II)-catalyzed lactonization homoallylic alcohols with alkynamides has been reported. The hydroxyl group in terminal olefins cooperates amide to promote cyclization by suppressing β-H elimination. This process provides a route construct naturally occurring biologically multifunctional α-methylene-γ-lactones.
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