Gating of fear in prelimbic cortex by hippocampal and amygdala inputs.

摘要: The prefrontal cortex (PFC) regulates emotional responses, but it is unclear how PFC integrates diverse inputs to select the appropriate response. We therefore evaluated contribution of basolateral amygdala (BLA) and ventral hippocampus (vHPC) fear signaling in prelimbic (PL) cortex, a region critical for expression conditioned fear. In rats trained press food, BLA inactivation decreased activity projection cells PL, reduced PL tone responses. contrast, vHPC interneurons increased Consistent with hippocampal gating after extinction, pyramidal extinguished, not conditioned, rats. These results suggest circuit whereby gates amygdala-based Thus, deficient inhibition may underlie disorders, especially light volume observed depression PTSD.