A Bioinformatics Method for Identifying Q/N-Rich Prion-Like Domains in Proteins
作者： Eric D. Ross , Kyle S. MacLea , Charles Anderson , Asa Ben-Hur
DOI: 10.1007/978-1-62703-438-8_16
关键词:
摘要: Numerous proteins contain domains that are enriched in glutamine and asparagine residues, aggregation of some these has been linked to both prion formation yeast a number human diseases. Unfortunately, predicting whether given glutamine/asparagine-rich protein will aggregate proven difficult. Here we describe recently developed algorithm designed predict the propensity proteins. We discuss basis for algorithm, its limitations, usage online downloadable versions algorithm.
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