Antisense oligonucleotides for identifying drug targets and enhancing cancer therapies

作者: D. James Koropatnick , Randall W. Berg , Mark D. Vincent

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摘要: The present invention provides antisense oligonucleotides useful for identifying drug targets cancer therapies and enhancing current therapies. of the are complementary to thymidylate synthase mRNA affect expression at least one other gene. For enhancement therapies, such can be used in conjunction with standard chemotherapeutic agents order target synthase, as well appropriate targets. methods constitute improved application a variety cancers.

参考文章(4)
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T. Inomoto, T. Kitai, M. Ukikusa, K. Ino, H. Higashiyama, A. Arimoto, Y. Nakajima, T. Hanafusa, H. Awane, H. Kobayashi, Dihydropyrimidine dehydrogenase and thymidylate synthase in relation to 5-fluorouracil sensitivity of breast cancer European Journal of Cancer. ,vol. 35, ,(1999) , 10.1016/S0959-8049(99)81204-0