White matter deterioration in 15 months: latent growth curve models in healthy adults.

摘要: The goal of the study was to examine differences in trajectories change volume white matter hyperintensities (WMH) healthy adults within a relatively short period. We measured volumes periventricular and deep WMH frontal, temporal, parietal, occipital lobes volunteers (age 49–83) on 3 occasions, approximately 15 months apart. At baseline, 40 participants underwent magnetic resonance imaging (MRI), 37 returned for first 30 second follow-up. Latent growth curve models estimated variance mean examined their associations with age, sex, education, hypertension. In both regions types, positive association between age stronger among middle-aged became weaker older ages, as logarithmic function age. Individual variations were present initial but not progression. Frontal greater hypertensive participants, whereas lower education associated posterior volume. Thus, undergoes significant regional deterioration period, is negatively affected by vascular risk educational level.