Transfer and metabolism of dideoxyinosine by the perfused human placenta

摘要: Dideoxyinosine (DDI) has been recently approved for the treatment of AIDS. In anticipation its use in HIV-infected women during pregnancy, transfer and metabolism DDI by perfused human placenta have investigated. Transfer characteristics are those simple diffusion: clearance is same as that L-glucose (transfer index 0.98 +/- 0.09), it equivalent both directions across placenta, rate proportional to transplacental gradient over a very broad range (1 500 microM). Because extensive placental metabolism, only about one-half cleared (51 21%) transferred intact fetal circulation. No dideoxyadenine triphosphate, antiviral product DDI, could be detected following perfusion. Comparison pharmacological information on zidovudine (ZDV) indicates pregnancy with will expose fetus much less drug than if ZDV were used. may therefore effective infected fetus. However, uninfected an woman gain reduced exposure known toxic.